This book covers the concepts of molecular medicine and personalized medicine. Subsequent chapters cover the topics of genomics, transcriptomics, epigenomics, and proteomics, as the tools of molecular pathology and foundations of molecular medicine. These chapters are followed by a series of chapters that provide overviews of molecular medicine as applied broadly to neoplastic, genetic, and infectious diseases, as well as a chapter on molecular diagnostics. The volume concludes with a chapter that delves into the promise of molecular medicine in the personalized treatment of patients with complex diseases, along with a discussion of the challenges and obstacles to personalized patient care. The Molecular Basis of Human Cancer, Second Edition, is a valuable resource for oncologists, researchers, and all medical professionals who work with cancer.
As the molecular basis of human disease becomes better characterized, and the implications for understanding the molecular basis of disease becomes realized through improved diagnostics and treatment, Molecular Pathology, Second Edition stands out as the most comprehensive textbook where molecular mechanisms represent the focus. It is uniquely concerned with the molecular basis of major human diseases and disease processes, presented in the context of traditional pathology, with implications for translational molecular medicine. The Second Edition of Molecular Pathology has been thoroughly updated to reflect seven years of exponential changes in the fields of genetics, molecular, and cell biology which molecular pathology translates in the practice of molecular medicine. The textbook is intended to serve as a multi-use textbook that would be appropriate as a classroom teaching tool for biomedical graduate students, medical students, allied health students, and others (such as advanced undergraduates). Further, this textbook will be valuable for pathology residents and other postdoctoral fellows that desire to advance their understanding of molecular mechanisms of disease beyond what they learned in medical/graduate school. In addition, this textbook is useful as a reference book for practicing basic scientists and physician scientists that perform disease-related basic science and translational research, who require a ready information resource on the molecular basis of various human diseases and disease states. Explores the principles and practice of molecular pathology: molecular pathogenesis, molecular mechanisms of disease, and how the molecular pathogenesis of disease parallels the evolution of the disease Explains the practice of “molecular medicine and the translational aspects of molecular pathology Teaches from the perspective of “integrative systems biology Enhanced digital version included with purchase
Proceedings of a NATO ASI/Eleventh Course of the International School of Pure and Applied Biostructure, held in Erice, Sicily, Italy, May 21-June 1, 1990
Stay current with the latest discoveries in molecular and genomic research. Sweeping revisions throughout include eight brand-new chapters on: Tumor Suppressor Genes; Inflammation and Cancer; Cancer Systems Biology: The Future; Biomarkers Assessing Risk of Cancer; Understanding and Using Information About Cancer Genomes; The Technology of Analyzing Nucleic Acids in Cancer; Molecular Abnormalities in Kidney Cancer; and Molecular Pathology.
Reveals what leading experts have recently discovered about cancers caused by DNA alterations! The second edition of THE GENETICS OF CANCER, newly titled THE GENETIC BASIS OF HUMAN CANCERS, updates and informs on the most recent progress in genetic cancer research and its impact on patient care. With contributions by the foremost authorities in the field, this fascinating new edition reports on how to understand and predict tumor development - information that can enhance decision-making and advance genetic research. 2ND Edition Highlights NEW CHAPTERS: * Peutz-Jeghers syndrome * Juvenile polyposis syndrome * Tumor genome instability * Gene expression profiling in cancer * Pilomatricoma and pilomatrix carcinoma * Hereditary paragangliomas of the head and neck * Cylindromatosis * Familial cardiac myxomas and carney complex * Cancers of the oral cavity and pharynx * Genetic abnormalities in lymphoid malignancies THOROUGHLY REVISED: * Every chapter has been meticulously reviewed and revised to incorporate the most recent research and clinical findings * Includes a valuable introduction by renowned editors Vogelstein & Kinser* Features 150 MORE illustrations than the previous edition
This book covers the concepts of molecular medicine and personalized medicine. Subsequent chapters cover the topics of genomics, transcriptomics, epigenomics, and proteomics, as the tools of molecular pathology and foundations of molecular medicine. These chapters are followed by a series of chapters that provide overviews of molecular medicine as applied broadly to neoplastic, genetic, and infectious diseases, as well as a chapter on molecular diagnostics. The volume concludes with a chapter that delves into the promise of molecular medicine in the personalized treatment of patients with complex diseases, along with a discussion of the challenges and obstacles to personalized patient care. The Molecular Basis of Human Cancer, Second Edition, is a valuable resource for oncologists, researchers, and all medical professionals who work with cancer.
This richly illustrated atlas-like book provides a foundation for the biological and molecular understanding of how the mammary gland develops and how breast cancer originates. The main goal is to comprehensively review in ten chapters fundamental knowledge in breast cancer. New paradigms are described in which induction of differentiation in the mammary gland can promote prevention and cure of breast cancer. The book is extremely helpful both for clinicians treating patients and researchers looking for new avenues of development.
Begins with a clinically based description and classification of what cancer represents as a disease of cells, then continues with a review of the historical basis of the oncogene concept. It generates a general perspective on the genetic contributions to carcinogenesis as an integrated disease process.
Volume 6 is the first comprehensive compilation of the latest knowledge on the biochemistry and molecular biology of all human blood groups. This well-illustrated volume covers material of prime importance for future developments in blood transfusion.
Designed as a text for an advanced course in cancer biology, this book covers topics ranging from carcinogenesis and oncogenes to the biochemical basis of cancer diagnosis and chemotherapy.
This user-friendly reference provides a basic understanding of the molecular biology underlying pulmonary diseases. Presents the background information necessary to understand the impact that molecular biology has on pulmonary medicine. Chapters begin with a list of basic concepts and a summary of the state-of-the-art information for each disease, starting with a clinical-molecular point of view and concluding with an annotated bibliography. Features excellent color illustrations and a thorough appendix! Each chapter illustrates molecular biologic methods or concepts by showing how this method has provided new information about a pulmonary disease. Each chapter begins with a list ofbasic concepts to be discussed and ends with a selection of annotated references. The first chapter, Basics, covers the basic concepts of what DNA is, how it is organized to govern the making of proteins, and their application to pulmonary medicine. Thechapter on Tuberculosis explains how the polymerase chain reaction relates to the diagnosis of the disease. Plus, discussions of virulence and drug resistance illustrate the clinical relevance of cloning DNA and screening libraries. Amyotrophias Lateral Sclerosis includes coverage of the structure of chromosomes, how to find a gene by linkage analysis, site-directed mutagenesis, and programmed cell death or apoptosis. Cystic Fibrosis discusses deduction of protein structure from gene sequence, posttranscriptional processing of RNA, and posttranslational processing of proteins. Cystic Fibrosis also illustrates the clinical relevance of genetic screening, commercial production of recombinant proteins, and gene therapy. Lung Cancer and the Cell Cycle explores DNA replication and its regulation, oncogenes and anti-oncogenes, and DNA mutations. The appendix contains a glossary of terms with simple definitions.
