For epidemiologists, evolutionary biologists, and health-care professionals, real-time and predictive modeling of infectious disease is of growing importance. This book provides a timely and comprehensive introduction to the modeling of infectious diseases in humans and animals, focusing on recent developments as well as more traditional approaches. Matt Keeling and Pejman Rohani move from modeling with simple differential equations to more recent, complex models, where spatial structure, seasonal "forcing," or stochasticity influence the dynamics, and where computer simulation needs to be used to generate theory. In each of the eight chapters, they deal with a specific modeling approach or set of techniques designed to capture a particular biological factor. They illustrate the methodology used with examples from recent research literature on human and infectious disease modeling, showing how such techniques can be used in practice. Diseases considered include BSE, foot-and-mouth, HIV, measles, rubella, smallpox, and West Nile virus, among others. Particular attention is given throughout the book to the development of practical models, useful both as predictive tools and as a means to understand fundamental epidemiological processes. To emphasize this approach, the last chapter is dedicated to modeling and understanding the control of diseases through vaccination, quarantine, or culling. Comprehensive, practical introduction to infectious disease modeling Builds from simple to complex predictive models Models and methodology fully supported by examples drawn from research literature Practical models aid students' understanding of fundamental epidemiological processes For many of the models presented, the authors provide accompanying programs written in Java, C, Fortran, and MATLAB In-depth treatment of role of modeling in understanding disease control
Shared diseases among wildlife, livestock and humans, often transboundary, are relevant to public health and global economy, as being highlighted currently relative to the global COVID19 pandemic. Diseases at these interfaces also impact the conservation of biodiversity and must be considered when managing wildlife. While wildlife and domestic livestock have coexisted in dynamic systems for thousands of years, spillover disease risks are higher today than in the past due to global patterns of increasing close contact and interactions among wildlife, livestock and humans in the context of complex, diverse and numerous circumstances. Multidisciplinary studies of animal interfaces, especially those involving wildlife, therefore, must be brought to the forefront so that knowledge gaps can be realized and filled to inform managers and policy makers. In the first part of the book authors illustrate and discuss ecological and epidemiological concepts related to the interfaces, with a vision towards socio-ecological system health. In addition, the history of past animal interfaces provides the necessary perspective to focus current questions, better understand present situations, and informs how we can best approach the future. The second part discusses the myriad of similar and differing wildlife- livestock interfaces found around the world from a regional point of view. The third part focuses on how to assess the spatial and temporal overlap between livestock and wildlife, and authors present new technical innovations about how inter-transmissions between wild and domestic populations can be quantified. An overview of main modeling approaches available to quantify multi-host disease transmission at the wildlife/livestock interface, illustrated with specific-case studies, is also presented. Finally, the need for interdisciplinary approaches and a dedicated thematic field to approach the wildlife/livestock interfaces and create opportunities to promote wildlife–livestock coexistence is emphasized. The concluding chapter presents perspectives and directions to better understanding disease dynamics at the wildlife/livestock interface, global change and implications for the future. The changing distribution of interfaces, ongoing human and environmental changes (e. g. climate warming, changes in animal production systems, etc.) and their likely impacts and consequences for the interfaces and disease transmission processes are all discussed.
This book features recent research in mathematical modeling of indirectly and directly transmitted infectious diseases in humans, animals, and plants. It compiles nine not previously published studies that illustrate the dynamic spread of infectious diseases, offering a broad range of models to enrich understanding. It demonstrates the capability of mathematical modeling to capture disease spread and interaction dynamics as well as the complicating factors of various evolutionary processes. In addition, it presents applications to real-world disease control by commenting on key parameters and dominant pathways related to transmission. While aimed at early-graduate level students, the book can also provide insights to established researchers in that it presents a survey of current topics and methodologies in a constantly evolving field.
Produced amidst the still rippling effects of a pandemic and as the world experiences the increasing burden of global warming and a rapidly changing biosphere, the second edition of Parasitology: A Conceptual Approach offers a timely overview of the eukaryotic parasites affecting human health and the health of domestic and wild animals and plants. The book offers a broadly encompassing, integrative view of the phenomenon of parasitism and of the remarkable diversity of the world’s parasites. This second edition has been thoroughly updated on all aspects of parasitism, including expanded sections on parasite biodiversity, parasite genomes, the interface between parasitology and disease ecology, and applications of new techniques like CRISPR and gene drives for parasite control. Key selling features: Emphasis on a distinctive integrative and conceptual approach rather than the taxon-by-taxon approach used in most parasitology books A concise, handy Rogues Gallery section that summarizes the basic biology for the most important eukaryotic parasites of humans and domestic animals, one a reader is repeatedly directed to throughout the chapters Outstanding full-color illustrations and photographs to reinforce key points The use of text boxes to set apart important topics or ideas that deserve special emphasis Provision of end-of-chapter summaries, questions to test understanding and key references for those wishing to seek further information Reference to particular URLs to highlight recent developments that often pose new and distinctive problems awaiting solution Parasitology: A Conceptual Approach is designed for an upper-level undergraduate audience, but its readability and careful explanation of underlying scientific concepts and terminology makes it appropriate for anyone seeking a broader understanding of the impact of infectious organisms on our well-being and the changes underway in the modern world.
Population Biology of Vector-Borne Diseases is the first comprehensive survey of this rapidly developing field. The chapter topics provide an up-to-date presentation of classical concepts, reviews of emerging trends, synthesis of existing knowledge, and a prospective agenda for future research. The contributions offer authoritative and international perspectives from leading thinkers in the field. The dynamics of vector-borne diseases are far more intrinsically ecological compared with their directly transmitted equivalents. The environmental dependence of ectotherm vectors means that vector-borne pathogens are acutely sensitive to changing environmental conditions. Although perennially important vector-borne diseases such as malaria and dengue have deeply informed our understanding of vector-borne diseases, recent emerging viruses such as West Nile virus, Chikungunya virus, and Zika virus have generated new scientific questions and practical problems. The study of vector-borne disease has been a particularly rich source of ecological questions, while ecological theory has provided the conceptual tools for thinking about their evolution, transmission, and spatial extent. Population Biology of Vector-Borne Diseases is an advanced textbook suitable for graduate level students taking courses in vector biology, population ecology, evolutionary ecology, disease ecology, medical entomology, viral ecology/evolution, and parasitology, as well as providing a key reference for researchers across these fields.
Author: Maria De Lourdes Ribeiro De Souza Da Cunha
Publisher: IntechOpen
ISBN: 9535105655
Category: Medical
Page: 408
View: 138
This book represents an overview on the diverse threads of epidemiological research, brings together the expertise and enthusiasm of an international panel of leading researchers to provide a state-of-the art overview of the field. Topics include the epidemiology of dermatomycoses and Candida spp. infections, the epidemiology molecular of methicillin-resistant Staphylococcus aureus (MRSA) isolated from humans and animals, the epidemiology of varied manifestations neuro-psychiatric, virology and epidemiology, epidemiology of wildlife tuberculosis, epidemiologic approaches to the study of microbial quality of milk and milk products, Cox proportional hazards model, epidemiology of lymphoid malignancy, epidemiology of primary immunodeficiency diseases and genetic epidemiology family-based. Written by experts from around the globe, this book is reading for clinicians, researchers and students, who intend to address these issues.
Author: Maria De Lourdes Ribeiro De Souza Da Cunha
Publisher: IntechOpen
ISBN: 9535105655
Category: Medical
Page: 408
View: 780
This book represents an overview on the diverse threads of epidemiological research, brings together the expertise and enthusiasm of an international panel of leading researchers to provide a state-of-the art overview of the field. Topics include the epidemiology of dermatomycoses and Candida spp. infections, the epidemiology molecular of methicillin-resistant Staphylococcus aureus (MRSA) isolated from humans and animals, the epidemiology of varied manifestations neuro-psychiatric, virology and epidemiology, epidemiology of wildlife tuberculosis, epidemiologic approaches to the study of microbial quality of milk and milk products, Cox proportional hazards model, epidemiology of lymphoid malignancy, epidemiology of primary immunodeficiency diseases and genetic epidemiology family-based. Written by experts from around the globe, this book is reading for clinicians, researchers and students, who intend to address these issues.
One Health is an emerging concept that aims to bring together human, animal, and environmental health. Achieving harmonized approaches for disease detection and prevention is difficult because traditional boundaries of medical and veterinary practice must be crossed. In the 19th and early 20th centuries this was not the case—then researchers like Louis Pasteur and Robert Koch and physicians like William Osler and Rudolph Virchow crossed the boundaries between animal and human health. More recently Calvin Schwabe revised the concept of One Medicine. This was critical for the advancement of the field of epidemiology, especially as applied to zoonotic diseases. The future of One Health is at a crossroads with a need to more clearly define its boundaries and demonstrate its benefits. Interestingly the greatest acceptance of One Health is seen in the developing world where it is having significant impacts on control of infectious diseases.
The Transformational Medical Technologies (TMT) has been a unique component of the U.S. Department of Defense (DoD) medical biodefense efforts since 2006. Its mission is to advance countermeasure research and development in support of the broader goal of the DoD to protect warfighters from emerging infectious diseases and future genetically engineered biological weapons. The TMT, using advanced science and technology approaches, focused on the development of roadspectrum countermeasures that target common host and pathogen pathways or enhance the host's immune response. Many of these pathogens are lethal or cause such debilitating diseases in humans that it is ethically inappropriate to test the efficacy of these countermeasures in human volunteers. In lieu of human participants, these products may be tested in animals and approved for human use under the provisions of the Food and Drug Administration (FDA)'s 2002 Animal Rule. The reliance on animal models for the development and licensure of medical countermeasures against biothreats is challenging for a number of reasons. The ad hoc Committee on Animal Models for Assessing Countermeasures to Bioterrorism Agents prepared a consensus report that would address the challenges stemming from developing and testing medical countermeasures against biothreat agents in animal models. Animal Models for Assessing Countermeasures to Bioterrorism Agents evaluates how well the existing TMT-employed or candidate animal models reflect the pathophysiology, clinical picture, and treatment of human disease as related to the agents of interest. The report addresses the process and/or feasibility of developing new animal models for critical biodefense research, placing emphasis on the need for a robust and expeditious validation process in terms of the FDA's Animal Rule. The report also evaluates alternatives to the use of animal models based on the premise of the Three Rs.
Animal Models for the Study of Human Disease identifies important animal models and assesses the advantages and disadvantages of each model for the study of human disease. The first section addresses how to locate resources, animal alternatives, animal ethics and related issues, much needed information for researchers across the biological sciences and biomedicine.The next sections of the work offers models for disease-oriented topics, including cardiac and pulmonary diseases, aging, infectious diseases, obesity, diabetes, neurological diseases, joint diseases, visual disorders, cancer, hypertension, genetic diseases, and diseases of abuse. Organized by disease orientation for ease of searchability Provides information on locating resources, animal alternatives and animal ethics Covers a broad range of animal models used in research for human disease
